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An investigation into the effect of several novel well-designed guanidinium salt ionic liquids(GILs) on inhibitting tumor growth is described. The GILs which have longer alkyl chain(6―18 carbon atoms) exhibit the high cytotoxicity to Hela299, B16 and SMMC-7721 cells so as to inhibit their proliferation. The inhibitory effect of the most effective GIL12 is about 10-fold higher than that of MMC(a common chemotherapy drug in clinic).
The investigation into the effect of several novel well-designed guanidinium salt ionic liquids (GILs) on inhibits tumor growth is described. The GILs have longer alkyl chain (6-18 carbon atoms) exhibit the high cytotoxicity to Hela 299, B16 and SMMC- 7721 cells so as to inhibit their proliferation. The inhibitory effect of the most effective GIL12 is about 10-fold higher than that of MMC (a common chemotherapy drug in clinic).