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目的 :探讨血清MIP-2、IL-6及CRP水平对心衰合并肺部感染患者的诊断价值。方法 :分析2014年1月~2015年12月87例在我院接受心力衰竭患者的临床资料,其中42例合并肺部感染列为观察组,45例单纯患有心力衰竭的患者划为对照组。结果 :观察组患者血清MIP-2及CRP水平明显高于对照组,差异具有统计学意义;观察组患者随着心功能分级的升高,血清中MIP-2、CRP水平随之升高,差异具有统计学意义。观察组Ⅳ级患者血清中IL-6水平明显高于Ⅱ级和Ⅲ级患者,差异具有统计学意义;ROC曲线显示,当MIP-2取值62.01pg/mL时对心衰合并肺部感染患者的诊断敏感性为90.48%,特异性88.89%,诊断价值优于IL-6及CRP。结论 :MIP-2、IL-6及CRP可作为对心衰合并肺部感染患者诊断指标,其中以MIP-2的诊断价值较高,对心衰合并肺部感染患者的诊断和治疗具有一定的临床研究价值。
Objective: To investigate the diagnostic value of serum MIP-2, IL-6 and CRP levels in patients with heart failure and pulmonary infection. Methods: The clinical data of 87 patients with heart failure admitted to our hospital from January 2014 to December 2015 were analyzed. Among them, 42 patients with pulmonary infection were classified as observation group and 45 patients with simple heart failure were classified as control group . Results: The levels of serum MIP-2 and CRP in the observation group were significantly higher than those in the control group, and the difference was statistically significant. The level of MIP-2 and CRP in the observation group increased with the increase of heart function, has statistical significane. The level of IL-6 in the serum of patients in observation group Ⅳ was significantly higher than that in patients of grade Ⅱ and Ⅲ, and the difference was statistically significant. The ROC curve showed that when the value of MIP-2 was 62.01pg / mL, The diagnostic sensitivity was 90.48% and the specificity was 88.89%. The diagnostic value was better than that of IL-6 and CRP. Conclusions: MIP-2, IL-6 and CRP can be used as diagnostic indicators in patients with heart failure and pulmonary infection. Among them, the diagnostic value of MIP-2 is higher, and the diagnosis and treatment of patients with heart failure and pulmonary infection have certain Clinical research value.