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目的:探讨胱硫醚-β合酶(cystathionine beta-synthase,CBS)和硫化氢(H2S)在慢性脑供血不足(chron-ic cerebral circulation insufficiency,CCCI)发病机制中的作用及与CCCI高危因素的关系。方法:采用ELISA试剂盒和分光光度法分别检测98例CCCI患者和108名健康体检者的血清CBS、H2S含量,并按年龄、性别及合并症对两组含量测定结果进行分层比较,分析CCCI高危因素与血清CBS、H2S水平的关系。结果:⑴CCCI患者血清CBS、H2S水平均明显低于健康对照组(P<0.01);⑵4个年龄段CCCI患者血清CBS、H2S水平均明显低于同年龄段健康对照组(P均<0.01);⑶CCCI患者中,大于60岁、男性及合并高血压和/或糖尿病亚组的血清CBS、H2S水平分别明显低于55岁以下、女性及无合并症亚组(P均<0.01)。结论:血清CBS、H2S可能参与CCCI的发病过程,且其水平可能与CCCI高危因素相关。
Objective: To investigate the role of cystathionine beta-synthase (CBS) and hydrogen sulfide (H2S) in the pathogenesis of chronic cerebral hypoperfusion (CCCI) and the relationship with the risk factors of CCCI relationship. Methods: Serum CBS and H2S levels in 98 CCCI patients and 108 healthy volunteers were detected by ELISA kit and spectrophotometry. The results of the two groups were compared by age, gender and comorbidity. The results of CCCI Relationship between risk factors and serum CBS, H2S levels. Results: (1) The levels of CBS and H2S in patients with CCCI were significantly lower than those in healthy controls (P <0.01). The serum CBS and H2S levels of CCCI patients in 4 age groups were significantly lower than those in the same age group (all P <0.01). In patients with CCCI, serum CBS and H2S levels were significantly lower in men older than 60 years, men and patients with hypertension and / or diabetes subgroups, respectively, under 55 years of age, women and no complications (P <0.01). Conclusion: Serum CBS and H2S may participate in the pathogenesis of CCCI, and their levels may be related to the risk factors of CCCI.