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目的 探讨II型糖尿病 (NIDDM )病人的血糖控制情况对糖尿病肾病 (DN)发生的影响。方法 对合并有DN及未合并有DN的NIDDM患者进行配对病例对照研究 ,共 10 6对。采用硫柳酸法测定 2 4h尿中总蛋白含量 ,根据患DM以来 (对于已患DN的患者 ,至其发生DN前 ) ,平均空腹血糖值 (FBG)是否 >140mg/dl来评估血糖控制情况。对资料进行条件logistic回归分析。 结果 单因素结果显示 :血糖控制情况与DN有统计学联系 ,比值比 (OR)及其 95 %的可信区间 (CI)分别为 0 .43( 0 .2 5～ 0 .75 ) ,用可能起混杂作用的因素调整后 ,这种关系仍然存在。结论 良好的血糖控制可减少NIDDM患者合并DN的危险 ,其作用独立于其它危险因素 (包括DM病程 )。
Objective To investigate the effect of glycemic control in patients with type 2 diabetes (NIDDM) on the occurrence of diabetic nephropathy (DN). Methods A matched case-control study was performed on NIDDM patients with or without DN and a total of 106 pairs. Twenty-four hours urine total protein was measured by the thio-salicylate method and glycemic control was assessed based on whether the mean fasting plasma glucose (FBG) was> 140 mg / dl for patients who had been suffering from DN up to their onset of DN . Data logistic regression analysis. Results The results of univariate analysis showed that there was statistical relationship between glycemic control and DN. The odds ratio (OR) and 95% confidence interval (CI) were 0.43 (0.52 ~ 0.75) The relationship is still present after a mix of factors has been adjusted. Conclusions Good glycemic control can reduce the risk of DN in patients with NIDDM and its effect is independent of other risk factors, including the course of DM.