扑热息痛在肝脏与葡萄糖醛酸-硫酸盐结合,经肾脏排泄。并形成少数具有氧化活性的代谢产物,通常它们与谷胱甘肽结合而解毒。当大剂量扑热息痛进入体内,肝内谷胱甘肽耗尽,具有氧化活性的代谢产物积聚,与肝细胞蛋白共价结合,致肝细胞坏死。现确认,摄入超剂量(10克)扑热息痛,在4小时内入院的病人,须进行常规中毒处理(洗 Paracetamol is bound to glucuronide-sulfate in the liver and is excreted by the kidneys. And the formation of a small number of oxidative activity of metabolites, usually they combined with glutathione detoxification. When large doses of paracetamol enter the body, glutathione depletion in the liver, the accumulation of metabolites with oxidative activity, and the covalent attachment of hepatocyte proteins, resulting in liver cell necrosis. It is confirmed that overdose (10 grams) of paracetamol, admitted to the hospital within 4 hours, must be routine poisoning (wash