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目的评价胸部放疗在广泛期小细胞肺癌(SCLC)治疗中的疗效及可行性。方法选取2011年1月—2014年3月山东省德州市临邑县人民医院收治的广泛期SCLC患者98例。其中男性87例,女性11例;平均年龄(60±5)岁。将患者随机分为A、B两组。A组给予同步放化疗;B组给予单纯化疗。比较两组的治疗效果、患者生活质量以及2年时存活率。结果治疗后,两组在进展(PD)人数上差异有统计学意义(P<0.05),而在完全缓解(CR)、部分缓解(PR)、稳定(NC)人数上差异无统计学意义(P>0.05);在恶心呕吐、腹泻人数上差异有统计学意义(P<0.05),而在血液毒性和疲劳人数上差异无统计学意义(P>0.05);在2年存活人数上差异有统计学意义(P<0.05)。结论胸部放疗在伴有远处转移的广泛期SCLC治疗中具有提高疗效,改善患者生存质量,提高2年存活率的效果。
Objective To evaluate the efficacy and feasibility of chest radiotherapy in the treatment of extensive stage small cell lung cancer (SCLC). Methods From January 2011 to March 2014, 98 patients with extensive stage SCLC were enrolled in Linyi County People’s Hospital of Dezhou, Shandong Province. There were 87 males and 11 females with an average age of (60 ± 5) years. The patients were randomly divided into A, B two groups. Group A received concurrent chemoradiotherapy; Group B received chemotherapy alone. The therapeutic effects, patient quality of life, and survival at 2 years were compared between the two groups. Results After treatment, there was significant difference in PD between the two groups (P <0.05), but there was no significant difference in the number of patients with complete remission (CR), partial remission (PR) and stable (NC) P> 0.05). There was a significant difference in the number of nausea, vomiting and diarrhea (P <0.05), but there was no significant difference in the number of hematological toxicity and fatigue (P> 0.05) Statistical significance (P <0.05). Conclusions Thoracic radiotherapy has the effect of improving curative effect, improving quality of life and increasing survival rate of 2 years in extensive SCLC with distant metastasis.