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目的探讨克罗米酚(CC)治疗多囊卵巢综合征(PCOS)的疗效,指导治疗方案的选择。方法 84例PCOS患者服CC前后测定血清生殖激素水平、超声了解卵巢形态并监测排卵。结果卵泡早期LH、FSH、LH/FSH、E2、T在无反应组和有反应组间差异无显著性(P>0.05);卵泡晚期和黄体中期:无反应组LH、FSH、E2及黄体高峰期P均低于有反应组,两组间差别显著(P<0.05);无反应组平均卵巢容积显著大于有反应组(P<0.01),平均卵泡数及平均髓质容积也大于有反应组(P<0.05)。结论卵巢三维超声形态评价结合血清生殖激素测定可初步预测CC疗效,对临床选择治疗方案有重要指导价值。
Objective To investigate the efficacy of clomiphene citrate (CC) in the treatment of polycystic ovary syndrome (PCOS) and to guide the choice of treatment options. Methods 84 cases of PCOS patients before and after taking CC serum reproductive hormone levels, ultrasound understanding of ovarian morphology and ovulation monitoring. Results There were no significant differences in LH, FSH, LH / FSH, E2, T between the non-reaction group and the response group in the early follicular phase (P> 0.05) (P <0.05). The average ovarian volume in non-reaction group was significantly greater than that in response group (P <0.01), and the average number of follicles and the average medullary volume were also greater than those in response group (P <0.05). Conclusion The ovarian three-dimensional ultrasound morphological evaluation combined with serum reproductive hormones can be a preliminary prediction of the efficacy of CC, the clinical choice of treatment programs have important guiding value.