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目的探讨参附注射液联合阿托伐他汀对慢性心力衰竭患者氧化应激和心室重构的影响。方法选择郸城县人民医院2009年9月至2011年9月慢性心力衰竭患者80例,随机分为观察组和对照组各40例。对照组采用常规抗心力衰竭治疗,观察组在常规治疗基础上给予阿托伐他汀和参附注射液。观察两组治疗后临床症状改善情况;测定两组患者治疗前后超氧化物歧代酶活性、丙二醛含量及基质金属蛋白酶-9水平;观察两组患者治疗前后心功能改善情况。结果观察组治疗后临床症状改善优于对照组,差异有统计学意义(P<0.05);观察组治疗后超氧化物歧代酶活性升高、丙二醛含量下降、基质金属蛋白酶-9水平降低,均优于对照组,差异有统计学意义(P<0.05);观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论参附注射液联合阿托伐他汀有助于增强慢性心力衰竭患者体内抗氧化应激能力,有助于抑制心室重构,改善心功能,临床疗效显著。
Objective To investigate the effects of Shenfu injection combined with atorvastatin on oxidative stress and ventricular remodeling in patients with chronic heart failure. Methods 80 patients with chronic heart failure in Dancheng People’s Hospital from September 2009 to September 2011 were randomly divided into observation group (40 cases) and control group (40 cases). The control group was treated with conventional anti-heart failure. The observation group was given atorvastatin and Shenfu injection on the basis of routine treatment. The clinical symptoms of the two groups were observed after treatment. The activity of superoxide dismutase, the content of malondialdehyde and the level of matrix metalloproteinase-9 in both groups were measured before and after treatment. The improvement of cardiac function in both groups before and after treatment was observed. Results The improvement of clinical symptoms in the observation group was better than that in the control group (P <0.05). After the treatment, the activity of superoxide dismutase increased, the content of malondialdehyde decreased, the level of matrix metalloproteinase-9 (P <0.05). The total effective rate in the observation group was higher than that in the control group, the difference was statistically significant (P <0.05). Conclusion Shenfu injection combined with atorvastatin can enhance the ability of anti-oxidative stress in patients with chronic heart failure, help to inhibit ventricular remodeling and improve cardiac function, with significant clinical efficacy.