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目的探讨中度高海拔地区人群叶酸营养水平与促红细胞生成素的关系。方法以2014年1月至2014年8月来自云南省弥勒市三个镇(海拔>1 000 m)的健康人群485例为研究对象,进行问卷调查、体格检查,同时进行血常规、血清促红细胞生成素(EPO)、血脂四项以及血清叶酸检测,按照血清叶酸浓度将研究对象分为高、中、低血清叶酸组,运用多变量一般线性模型以及Spearman秩相关分析,分析叶酸和EPO之间的关联性。结果中度高海拔地区人群,在低、中、高血清叶酸浓度组间,血清EPO水平不同,差异具有统计学意义(P<0.05);LDL-C在三组间差异也具有统计学意义(P<0.05);而RBC,Hb,TC,TG,HDL-C水平在三组间的差异无统计学意义(P>0.05);血清叶酸浓度与EPO呈正相关关系(rs=0.731,P<0.001),与Hb呈负相关关系(rs=-0.101、P<0.05),与RBC的相关系数无统计学意义。结论中度高海拔人群的血清叶酸浓度与血清EPO明显相关,血清叶酸浓度高者其血清EPO也较高,提示保持良好的叶酸营养状况有益于中度高海拔地区人群维持血清高EPO水平。
Objective To investigate the relationship between folic acid supplementation and erythropoietin in moderate high altitude areas. Methods From January 2014 to August 2014, 485 healthy subjects from three towns (above 1 000 m above sea level) in the city of Maitre in Yunnan Province were enrolled in this study. Questionnaires and physical examinations were performed. Blood samples, serum erythrocyte EPO, serum lipids and serum folic acid. The subjects were divided into high, middle and low serum folic acid group according to serum folate concentration. Multivariate general linear model and Spearman rank correlation analysis were used to analyze the relationship between folic acid and EPO The relevance of. Results There were significant differences in serum EPO levels between moderately high altitude and low, middle and high levels of serum folate levels (P <0.05). LDL-C also had statistical significance among the three groups (P < (P> 0.05). The levels of RBC, Hb, TC, TG and HDL-C in the three groups had no statistical significance (P> 0.05) ), But negatively correlated with Hb (rs = -0.101, P <0.05), but no correlation with RBC was found. Conclusions Serum folic acid concentration is significantly correlated with serum EPO in moderately high altitude people. Serum levels of EPO are also high in patients with high concentrations of serum folic acid, suggesting that maintaining good folic acid nutritional status is beneficial to maintaining high serum EPO level in moderate high altitude people.