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组胺H_2受体拮抗剂甲氰咪胍系治疗消化性溃疡病的有效药物,特别是对十二指肠溃疡的愈合已被公认。到1978年终已有90多个国家用之于临床。 1.对其他药物吸收的影响 甲氰咪胍通过抑制胃酸的分泌而发挥其作用,可使胃液的pH值提高到3-5。胃液中pH值的改变就会减少进入全身循环的药量。这些理论提供了下列药物与甲氰咪胍相互作用的基础。 1.1 四环素 胃液pH值的提高,可减少四环素的溶解与吸收。四环素与甲氰眯胍的相互作用有一定的临床意义,溃疡病患者
Histamine H 2 Receptor Antagonist Cimetidine is an effective drug for the treatment of peptic ulcer disease, especially for the healing of duodenal ulcers. By the end of 1978, more than 90 countries had used it for clinical purposes. 1. Effects on Other Drugs Cimetidine exerts its effect by inhibiting the secretion of gastric acid, which increases the gastric pH to 3-5. Changes in the pH of the gastric juice will reduce the amount of drug entering the systemic circulation. These theories provide the basis for the following drug interactions with cimetidine. 1.1 tetracycline gastric pH increase, can reduce the dissolution and absorption of tetracycline. The interaction of tetracycline and cyanamide has certain clinical significance, patients with ulcer disease