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目的:探讨肾康注射液对肾小管上皮细胞LLC-PK1增殖的影响。方法:以单味大黄注射液为实验对照组,采用MTT比色法测定肾康注射液对LLC-PK1细胞增殖的影响。结果:肾康注射液明显抑制肾小管上皮细胞LLC-PK1的增殖并呈剂量依赖关系;肾康注射液作用明显优于同等含量的单味大黄注射液。结论:抑制肾小管上皮细胞增殖是肾康注射液防治慢性肾功能衰竭、延缓肾功能持续恶化的重要机理之一。
Objective: To investigate the effect of Shenkang injection on the proliferation of renal tubular epithelial cells LLC-PK1. Methods: The single-flavored rhubarb injection was used as the experimental control group. The effect of Shenkang injection on the proliferation of LLC-PK1 cells was determined by MTT assay. RESULTS: Shenkang injection significantly inhibited the proliferation of LLC-PK1 in renal tubular epithelial cells in a dose-dependent manner. The effect of Shenkang injection was significantly better than that of the same content of Danwei Dahuang injection. Conclusion: Inhibiting the proliferation of renal tubular epithelial cells is one of the important mechanisms of Shenkang injection in preventing and treating chronic renal failure and delaying the continuous deterioration of renal function.