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目的 :探讨柳氮磺胺吡啶 (SASP)和甲氨喋呤 (MTX)治疗类风湿性关节炎 (RA)的疗效。方法 :选择 32例RA患者 ,经口服SASP 1 0g ,每日 2次 ,MTX 10mg,每周 1次 ,治疗 1年后 ;用双抗体夹心ELISA方法检测血清SIL 2R变化 ,评价其疗效。结果 :类风湿性关节炎组血清SIL 2R水平明显高于健康人 (P <0 0 1) ,治疗后临床缓解率 18 8% ,显效率 5 3 1% ,有效率 15 6 % ,总有效率达 87 5 % ,无效率 12 5 %。治疗前后血清SIL 2R比较 ,除无效组 (P >0 0 5 )外 ,差异均有显著意义 (P <0 0 1)。结论 :SASP +MTX治疗RA ,疗效肯定 ,治疗后血清SIL 2R明显下降。血清SIL 2R的测定可作为判断RA病情及指导治疗的一个重要的监测指标。
Objective: To investigate the curative effect of sulfasalazine (SASP) and methotrexate (MTX) on rheumatoid arthritis (RA). Methods: Thirty-two patients with RA were randomly divided into two groups: SASP 10g, twice a day, MTX 10mg once a week for 1 year. Serum SIL 2R level was measured by double antibody sandwich ELISA to evaluate the therapeutic effect. Results: The level of serum SIL 2R in rheumatoid arthritis group was significantly higher than that in healthy people (P <0.01). After treatment, the clinical remission rate was 18.8%, the effective rate was 51.3% and the effective rate was 15.6%. The total effective rate 87 5%, inefficiency 125%. The levels of serum SIL 2R before and after treatment were significantly different (P <0.01) except for the invalid group (P> 0.05). Conclusion: SASP + MTX treatment of RA, positive effect, serum SIL 2R decreased significantly after treatment. Determination of serum SIL 2R can be used as a judge of RA disease and guide treatment of an important monitoring indicators.