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扁平苔藓(LP)的恶变尚有争论,大多数报告其恶变率在0.2％～10％,主要为糜烂型。作者描述了8204份标本中的280例临床或病理诊断为OLP,以后经活检证实有恶变或癌前病变的8例患者的变化情况。8例患者中男性2例,女性6例。诊断为LP时年龄15～76岁(平均46岁)。开始恶变年龄34～76岁(平均51岁)。5例同时诊断为LP和恶变,其病损的周围为LP,中央已恶变。2例在第一次证实为OLP后7年恶变,另一例在24年后恶变。多数病例临床上诊断为糜烂型,
Malignant transformation of lichen planus (LP) is still controversial, most reports of malignant transformation rate of 0.2% to 10%, mainly erosive. The authors describe the changes in 280 patients with OLP clinically or pathologically diagnosed in 8204 specimens and 8 patients who were subsequently confirmed to have malignant or precancerous lesions by biopsy. In 8 cases, there were 2 males and 6 females. The diagnosis of LP age 15 to 76 years (mean 46 years). Start malignant age 34 to 76 years (mean 51 years). 5 cases were diagnosed as LP and malignant transformation, the lesions around the LP, the central malignant. Two patients had malignant transformation at 7 years after OLP was first confirmed, and the other became malignant after 24 years. Most cases of clinical diagnosis of erosive type,