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目的：探索用于靶向载药系统的材料与制剂方法。方法：以溶解淀粉为原料，环氧氯丙烷为交联剂，Ｆｅ３Ｏ４为磁性材料，采用逆相悬浮交联聚合机制合成了中性磁性淀粉微球（ＥＳＭ，一种用环氧氯丙烷作交联剂的淀粉微球）。以其为原料，用Ｎａ３Ｐ３Ｏ９作交联剂进行二次交联和阴离子化，得到一种阴离子型磁性淀粉微球（ＴＳＭ，一种用三聚偏磷酸钠作交联剂的淀粉微球）。研究了上述两种微球的表观形态、粒径分布、溶胀性、载药性能和体外磁响应性。结果：两种磁性微球的各项性质符合设计要求。结论：以溶解淀粉代替预糊化淀粉，１～２μｍ粒径的Ｆｅ３Ｏ４代替３０μｍ以下小粒径磁质制备磁性微球是可行的
OBJECTIVE: To explore methods and materials for targeted drug delivery systems. Methods: Neutral magnetic starch microspheres (ESM) were synthesized by dissolving starch, epichlorohydrin as cross-linking agent and Fe3O4 as magnetic material by reverse phase suspension cross-linking polymerization Co-agent of starch microspheres). Using it as a raw material, secondary crosslinking and anionization with Na3P3O9 as a cross-linking agent were carried out to obtain an anionic magnetic starch microsphere (TSM, a starch microsphere with sodium tripolyphosphate as a cross-linking agent). The morphologies, particle size distributions, swelling properties, drug loading properties and in vitro magnetic responsiveness of the two microspheres were investigated. Results: The properties of the two magnetic microspheres meet the design requirements. Conclusion: It is feasible to prepare magnetic microspheres by dissolving starch instead of pregelatinized starch and Fe3O4 with the size of 1 ~ 2μm instead of smaller than 30μm.