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目的:比较糖尿病合并牙周炎患者、单纯糖尿病患者、单纯牙周炎患者以及健康者全唾液中降钙素原(Pro-CT)水平,及其与血糖控制情况及牙周病炎严重程度之间的关系。方法:采用病例对照研究,纳入糖尿病合并牙周炎患者(DM+CP组)24例,单纯糖尿病患者(DM组)、单纯牙周炎患者(CP组)以及健康人群各30例,收集受检者静息全唾液,采用酶联免疫吸附试验(ELISA)检测全唾液中Pro-CT水平。结果:DM+CP组全唾液中ProCT水平显著高于其他3组,差异极具统计学意义(P<0.01);全唾液中Pro-CT水平随牙周炎严重程度加重而增高,随血糖控制情况的不理想而增高,差异有统计学意义;全唾液中Pro-CT水平与探诊深度(PD)、探诊出血指数(BI)、附着丧失(AL)、缺失牙数均呈正相关,且相关程度由高到低依次为PD、BI、AL、缺失牙数,差异有统计学意义(P<0.05)。结论:糖尿病患者体内的微炎症状态可能与牙周炎症有关,全唾液中Pro-CT水平既受牙周炎症影响也受全身因素的调控。
Objective: To compare the level of Pro-CT in whole saliva of patients with diabetes mellitus, simple diabetic patients, simple periodontitis and healthy persons, and to compare their relationship with the control of blood glucose and the severity of periodontitis Relationship between. Methods: A case-control study was conducted in 24 DM patients with diabetes mellitus (DM + CP group), DM patients (DM group), simple periodontitis patients (CP group) and 30 healthy individuals. Resting whole saliva, Pro-CT levels in whole saliva were detected by enzyme-linked immunosorbent assay (ELISA). Results: The level of ProCT in whole saliva of DM + CP group was significantly higher than that of the other three groups (P <0.01). Pro-CT level in total saliva increased with the severity of periodontitis, The level of pro-CT in total saliva was positively correlated with PD, bleeding index (BI), attachment loss (AL) and missing teeth number, and the difference was statistically significant Correlation degree descending order of PD, BI, AL, missing teeth, the difference was statistically significant (P <0.05). Conclusion: The state of micro-inflammation in diabetic patients may be related to periodontal inflammation. The level of Pro-CT in whole saliva is affected both by periodontal inflammation and by systemic factors.