从地衣 Aspicilin calcarea Muld.中分出一大环内酯,并证明其结构为(Ⅰ)式。取空气干燥地衣粉末184克,以200毫升乙醚提取12小时,乙醚液用10毫升1%NaOH 振摇后,干燥,除去乙醚,提取物溶于200毫升苯,以50克硅胶层析。先以500毫升苯及500毫升苯-乙醚(8:2)洗脱,以除去腊质及油状物。再以1升乙醚洗脱,得350毫克 aspicilin 粗制品,经甲醇及乙醚-已烷重 A macrolide was isolated from the lichen Aspicilin calcarea Muld. And its structure was shown as (I). The air-dried lichen powder 184 g was extracted with 200 ml of ether for 12 hours. The ether solution was shaken with 10 ml of 1% NaOH, dried and the ether was removed. The extract was dissolved in 200 ml of benzene and chromatographed on 50 g of silica gel. The first wash with 500 ml of benzene and 500 ml of benzene-diethyl ether (8: 2) to remove wax and oil. Then 1 liter of ether to give 350 mg aspicilin crude product, methanol and ether - hexane weight