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目的探讨瑞舒伐他汀对急性心肌梗死患者血清基质金属蛋白酶(matrix metalloproteinases,MMPs)及炎症因子水平的影响。方法选取宝鸡市千阳县人民医院和宝鸡市中心医院急性心肌梗死的老年患者76例,根据随机数字表法分为两组:对照组38例,予阿司匹林、阿托伐他汀等临床常规治疗;试验组38例,在常规治疗基础上加用瑞舒伐他汀,共治疗2周。观察两组患者治疗前后血清MMPs及炎症因子超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子(tumor necrosis factor-α,TNF-α)及白细胞介素-8(interleukin-8,IL-8)水平的变化,及治疗的临床效果。结果经2周治疗后,试验组患者临床疗效优于对照组,血清MMP-9、MMP-2水平低于对照组(P<0.05);血清hs-CRP、TNF-α及IL-8水平低于对照组(P<0.05);试验组治疗总有效率高于对照组,无效率低于对照组(P<0.05);试验组血管再通率高于对照组,血管闭塞率低于对照组(P<0.05)。结论瑞舒伐他汀能够降低急性心肌梗死患者血清MMPs水平,降低血清hs-CRP、TNF-α及IL-8等炎症因子水平,提高血管再通率,降低血管闭塞率,具有较好的临床疗效。
Objective To investigate the effect of rosuvastatin on serum matrix metalloproteinases (MMPs) and inflammatory cytokines in patients with acute myocardial infarction. Methods A total of 76 elderly patients with acute myocardial infarction from Qianyang County People ’s Hospital of Baoji City and Baoji Central Hospital were divided into two groups according to the random number table: control group (38 cases), routine treatment with aspirin and atorvastatin, In the experimental group, 38 cases were treated with rosuvastatin on the basis of routine treatment for 2 weeks. The levels of serum MMPs and hs-CRP, TNF-α and IL-8 in the two groups before and after treatment were observed. (interleukin-8, IL-8) levels, and the clinical effect of treatment. Results After 2 weeks of treatment, the clinical efficacy of the experimental group was better than that of the control group, and the levels of serum MMP-9 and MMP-2 were lower than those of the control group (P <0.05). The levels of serum hs-CRP, TNF- α and IL- (P <0.05). The total effective rate of the experimental group was higher than that of the control group, and the inefficiency rate was lower than that of the control group (P <0.05). The recanalization rate of the experimental group was higher than that of the control group, and the rate of vascular occlusion was lower than that of the control group (P <0.05). Conclusions Rosuvastatin can reduce the levels of serum MMPs, decrease the levels of inflammatory cytokines such as hs-CRP, TNF-α and IL-8 in patients with acute myocardial infarction, improve the recanalization rate and reduce the rate of vascular occlusion, which has a good clinical effect .