目的 :制备美洛昔康凝胶剂 ,研究其经皮吸收过程。方法 :采用双室渗透扩散装置 ,小鼠皮肤作为试验材料 ,进行体外渗透试验。结果 :油酸、红桧油、Azone、桉叶油均能有效地促进美洛昔康的渗透 ,其中油酸的渗透系数和增渗倍数比其他促进剂大。结论 :凝胶剂的最佳处方为 :0 .1%美洛昔康 ,2 %油酸 ,卡波普 /羟丙甲纤维素为2∶1;凝胶剂中药物的渗透可用Higuchi方程来描述。 Objective: To prepare meloxicam gel and study its percutaneous absorption process. Methods: Double-chamber osmotic diffusion device and mouse skin were used as experimental materials for in vitro penetration test. Results: Oleic acid, red juniper oil, Azone and Eucalyptus oil all can effectively promote the infiltration of meloxicam, and the osmotic coefficient and infiltration multiples of oleic acid are larger than those of other promoters. Conclusion: The best prescription of gel was: 0.1% meloxicam, 2% oleic acid and carbopol / hypromellose were 2:1. The penetration of drug in the gel could be got by Higuchi equation description.