论文部分内容阅读
目的:研究HDV对乙肝患者病情和HBV复制的影响。方法:HBVDNA采用聚合酶链反应法,抗-HDIgM、抗-HD、HDAg、HBVM采用酶链免疫吸附法。结果:重叠感染组白蛋白降低、凝血酶原时间延长、死亡率和并发肝肾综合症明显高于单纯乙肝组(P<0.05),病情加重速度快的病例多(P<0.05)。两组病例HBeAg、HB-VDNA阳性率无显著性差异(P>0.05)。结论:HBV与HDV重叠感染使肝炎病情加重且加重速度快,HDV对HBV复制无明显抑制。
Objective: To study the effect of HDV on the condition and HBV replication of hepatitis B patients. Methods: HBVDNA was detected by polymerase chain reaction, anti-HDIgM, anti-HD, HDAg and HBVM by enzyme-linked immunosorbent assay. Results: In the overlapping infection group, albumin, prolonged prothrombin time, mortality and concurrent hepatorenal syndrome were significantly higher than those in the simple hepatitis B group (P <0.05). The more severe cases were aggravated (P <0.05). There was no significant difference in the positive rates of HBeAg and HB-VDNA between the two groups (P> 0.05). Conclusion: Over-infection of HBV and HDV aggravates the severity of hepatitis and aggravates the severity of hepatitis. HDV has no obvious effect on HBV replication.