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目的:探讨初诊2型糖尿病患者采用瑞格列奈与二甲双胍联合治疗的临床效果。方法:选择2014年2月至2015年2月期间佛山市顺德区第一人民医院附属陈村医院收治的40例初诊2型糖尿病患者为研究对象,根据数字随机表法将其分为两组,其中给予对照组常规治疗,而观察组则运用二甲双胍与瑞格列奈联合治疗,对两组的治疗效果进行比较分析。结果:治疗前,两组的糖化血红蛋白(HbAlc)、餐后2 h血糖(2 hPPG)以及空腹血糖(FBG)水平对比,差异均无统计学意义(P>0.05);治疗后,与对照组相比,观察组的FBG、2 h PPG以及HbAlc水平明显下降,组间比较差异具有统计学意义(P<0.05);相比较对照组而言,观察组治疗有效率高,组间对比差异具有统计学意义(P<0.05);与对照组比较,观察组的不良反应发生率高,但是组间对比差异均无统计学意义(P>0.05);同时,两组的体质量指数(BMI)、低密度脂蛋白(LDL)、三酰甘油(TG)以及总胆固醇(TC)水平对比,差异具有统计学意义(P<0.05)。结论:临床上给予初诊2型糖尿病患者瑞格列奈与二甲双胍联合治疗,不仅可以有效控制血糖,还能改善血脂水平,提高治疗效果。
Objective: To investigate the clinical effect of combined treatment with repaglinide and metformin in newly diagnosed type 2 diabetic patients. Methods: From February 2014 to February 2015, 40 cases of newly diagnosed type 2 diabetes patients admitted to Chencun Hospital Affiliated to First People’s Hospital of Shunde District in Foshan City were selected and divided into two groups according to the digital random table method. Which give the control group conventional treatment, while the observation group is the use of metformin and repaglinide combined treatment of the treatment effect of the two groups were compared. Results: Before treatment, there was no significant difference in HbAlc, 2 hPGH and FBG between the two groups (P> 0.05). After treatment, compared with the control group Compared with the control group, FBG, 2 h PPG and HbA1c levels in the observation group decreased significantly (P <0.05), and the difference between the two groups was statistically significant (P <0.05). Compared with the control group, the incidence of adverse reactions in the observation group was high, but there was no significant difference between the two groups (P> 0.05). At the same time, the body mass index (BMI) , Low density lipoprotein (LDL), triglyceride (TG) and total cholesterol (TC), the difference was statistically significant (P <0.05). Conclusion: The combination of repaglinide with metformin in newly diagnosed type 2 diabetic patients can not only effectively control blood sugar, but also improve blood lipid level and improve the therapeutic effect.