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目的分析高血糖对慢性阻塞性肺疾病(COPD)肺功能的影响。方法将124例COPD患者分为单纯COPD组与COPD合并糖尿病组,其中COPD合并糖尿病组再根据糖尿病病程分为5年组,10年组,15年组。所有患者均行肺功能检查,记录TLC,FVC,FEV1,FEV1/FVC%,FEF25%~75%,及DLCO,DLCO/VA。结果进行t检验分析。结果COPD合并糖尿病组的DLCO,DLCO/VA显著低于单纯COPD组(P<0.05),COPD合并糖尿病组中10年组,15年组肺功能指标与5年组比较具有统计学意义(P<0.05)。结论高血糖使COPD患者的肺弥散功能进一步受损,而糖尿病病程长短与肺功能减退程度相关。
Objective To analyze the effect of hyperglycemia on pulmonary function in chronic obstructive pulmonary disease (COPD). Methods 124 patients with COPD were divided into two groups: COPD group and COPD group. COPD patients with diabetes mellitus group were divided into 5-year group, 10-year group and 15-year group according to their duration of diabetes mellitus. All patients underwent pulmonary function tests. TLC, FVC, FEV1, FEV1 / FVC%, FEF25% -75%, and DLCO, DLCO / VA were recorded. The results of t test analysis. Results The DLCO and DLCO / VA in COPD patients with diabetes mellitus were significantly lower than those in COPD patients (P <0.05). The COPD patients with diabetes mellitus had statistically significant differences in lung function between the 10 - and 15 - year groups and the 5 - year group (P < 0.05). Conclusion Hyperglycemia further impaired lung diffusion in patients with COPD, and the duration of diabetes is related to the degree of lung dysfunction.