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目的了解扬州市艾滋病患者高效抗逆转录病毒治疗(HAART)效果,分析影响因素,提高抗病毒治疗效果。方法调查并随访2005~2012年本地加入治疗的艾滋病患者,对CD4T淋巴细胞等进行分析。结果共调查HAART艾滋病患者154例,治疗第3、6、9、12、18、24个月的CD4T淋巴细胞计数逐步升高(P<0.01);治疗3个月时,经异性和同性传播途径的艾滋病患者CD4T淋巴细胞增加值低于经血液/血制品患者(P<0.05);治疗9个月时,已婚有配偶和离异或丧偶的患者CD4T淋巴细胞增加值低于未婚者(P<0.05);治疗18个月和24个月时,艾滋病病毒感染者CD4T淋巴细胞增加值高于艾滋病病人(P<0.01)。结论扬州市艾滋病抗病毒治疗工作取得成效,建议提早开展艾滋病抗病毒治疗,要关注治疗9个月内已婚有配偶和离异或丧偶患者的治疗指标。
Objective To understand the effect of highly active antiretroviral therapy (HAART) for AIDS patients in Yangzhou, analyze the influencing factors and improve the effect of antiviral therapy. Methods Investigate and follow-up of HIV-infected patients who were treated locally from 2005 to 2012, and analyzed CD4 T lymphocytes. Results A total of 154 patients with HAART AIDS were investigated. The counts of CD4 T lymphocytes in 3, 6, 9, 12, 18 and 24 months after treatment were gradually increased (P <0.01). At 3 months, (P <0.05). At 9 months of treatment, the added value of CD4 T lymphocytes in spouses with divorced or widowed spouses was lower than that of unmarried spouses (P < 0.05). At 18 and 24 months of treatment, CD4 T lymphocytes in HIV-infected patients were higher than those in AIDS patients (P <0.01). Conclusions The anti-virus treatment of HIV / AIDS in Yangzhou has achieved success. It is recommended that HIV / AIDS be treated as early as possible. Care should be taken for the treatment of married couples with spouses and divorced or widowed within 9 months.