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目的:了解转铁蛋白受体单克隆抗体与阿霉素偶联,制成阿霉素单抗偶联物,分别通过胃镜下瘤体直接注射,动脉插管灌注和静脉输注三种方法治疗对胃癌的疗效 方法:采用30%氧化葡聚糖偶联法,将转铁蛋白受体单克隆抗体与阿霉素通过葡聚糖Dextran-10按一定程序偶联.将阿霉素单抗偶联物分别通过胃镜下注射、动脉插管灌注和静脉输注三种方法治疗胃癌共同46例 结果:胃镜下注射、动脉插管灌注和静脉输注三种方法的总缓解率分别为46.67%(7/15),56.25%(9/16)和33.33%(5/15)出现毒副反应的例数分别3例,5例和6例.统计学比较,胃镜下注射组疗效与动脉插管灌注组无明显差异(p>0 05),比静脉输注组效果好(p<0.05),而毒副作用方而则前组明显少于后两组(P<0.05)结论:胃镜下瘤体直接注射与动脉插管灌注单抗偶联化疗药物治疗胃癌效果好,毒副反应少
OBJECTIVE: To investigate the coupling of transferrin receptor monoclonal antibody with adriamycin and the preparation of doxorubicin conjugates by direct injection under gastroscope, arterial catheterization and intravenous infusion. The efficacy of gastric cancer: 30% oxidized dextran coupling method, the transferrin receptor monoclonal antibody and doxorubicin dextran through Dextran-10 coupling according to a certain program. The doxorubicin monoclonal antibody The joint treatment of gastric cancer by gastroscope injection, arterial catheter perfusion and intravenous infusion, respectively, results in 46 cases: The total remission rate of gastroscope injection, arterial intubation perfusion and intravenous infusion were 46.67% ( 7/15), 56.25% (9/16) and 33.33% (5/15) cases of toxic side effects in 3 cases, 5 cases and 6 cases. Statistically, the effect of endoscopic injection group and arterial cannulation There was no significant difference in the perfusion group (p>0.05), which was better than the intravenous infusion group (p<0.05), while the toxic side effects were significantly less in the former group than in the latter two groups (P<0.05). Conclusions: Endoscopic tumors Direct Injection and Arterial Catheter Infusion of Monoclonal Antibody Coupling Chemotherapy Drugs for Gastric Cancer with Good Effects and Less Side Effects