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CRF07 BC是中国特有的艾滋病病毒Ⅰ型(HIV-1)重组毒株,首先在四川和新疆静脉吸毒人群中检出,并成为中国静脉吸毒人群中主要的流行毒株。从发现至今,CRF07 BC在中国流行时间超过十年,其流行呈逐步扩大的态势。对CRF07 BC的现场流行病学和分子流行病学研究也逾十年,积累了大量的现场流行病学数据和实验室数据。特别是2006年在中国台湾静脉吸毒人群中爆发了CRF07 BC流行,CRF07 BC的起源和传播路线等成了众所关注的焦点。该文对CRF07 BC的起源、分子流行病学研究等方面进行综述,希望对该毒株的预防控制、流行趋势和起源推测以及传播路线确立等研究提供依据。
CRF07 BC is a Chinese unique HIV-1 recombinant strain that was first detected in intravenous drug users in Sichuan and Xinjiang and became the major epidemic strain in intravenous drug users in China. Since its discovery, CRF07 BC has been in China for more than a decade and its popularity has been gradually expanding. Field epidemiological and molecular epidemiological studies of CRF07 BC have also been conducted for more than a decade, accumulating a large amount of field epidemiological and laboratory data. Especially in 2006, CRF07 BC epidemic broke out among intravenous drug users in Taiwan, China. The origin and route of CRF07 BC became the focus of attention. This review summarizes the origin, molecular epidemiology and other aspects of CRF07 BC in hope of providing a basis for the prevention and control, epidemiological trends, origin speculation and establishment of transmission routes of this strain.