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随着人们对造血微环境认识的不断深化,表明骨髓细胞外基质(ECM)并非一种被动的无活力结构支架,它们主要由三类不同的大分子物质组成:即糖蛋白、蛋白多糖和胶原,是造血细胞赖以传递与接受信息的物质基础,与血液系统疾病多种生理病理过程的发生机制密切联系。因此近年这一领域的研究日益活跃,现复习有关文献,简要综述如下。一、细胞外基质的组成糖蛋白(Glycoproteins) 是由糖基异头碳原子上的羟基与肽链
As people continue to deepen their understanding of the hematopoietic microenvironment, it indicates that the extracellular matrix (ECM) of bone marrow is not a passive scaffold without active structure. They mainly consist of three different types of macromolecules: glycoprotein, proteoglycan and collagen , Is the material basis for hematopoietic cells to transmit and receive information, and is closely linked to the pathogenesis of various physiological and pathological processes of hematological diseases. Therefore, in recent years, the research in this field is becoming more and more active. Now, I review the relevant literature and briefly summarize the following. First, the composition of the extracellular matrix Glycoproteins (Glycoproteins) is a sugar-based anomeric carbon atoms and peptide chains