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文章对10例健康人和7例急性肾功能衰竭(ARF)及8例慢性肾功能衰竭(CRF)患者的指甲肌酐和血肌酐进行测定,结果表明:健康人与ARF的指甲肌酐无显著差异(P>0.05),而ARF与CRF的指甲肌酐则有显著性差异(P<0.01);健康人与ARF的血肌酐有显著性差异(P<0.01),而ARF和CRF的血肌酐则无显著性差异(P>0.05).由此可见,血肌酐测定值不能作为急慢性肾功能衰竭的判别指标,而指甲肌酐的测定则可以作为鉴别急、慢性肾竭的指标.测定指甲肌酐可作为药物不良反应监测的重要指标.
The results of nail creatinine and serum creatinine in 10 healthy people, 7 patients with acute renal failure (ARF) and 8 patients with chronic renal failure (CRF) showed that there was no significant difference in nails creatinine among healthy subjects and ARF patients (P <0.01), while there was a significant difference between ARF and CRF (P <0.01); the serum creatinine of ARF and ARF was significantly different (P <0.01), but there was no significant difference between ARF and CRF (P> 0.05) .From this, we can see that the serum creatinine can not be used as a discriminant index for acute and chronic renal failure, while the determination of nail creatinine can be used as an index to distinguish acute and chronic renal failure. Adverse reaction monitoring of the important indicators.