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结缔组织生长因子(connective tissue growth factor,CTGF)是一种新的可刺激成纤维细胞增殖和分泌胶原的生长因子,具有促进肌成纤维细胞增殖、诱导细胞黏附、刺激细胞迁移和促进细胞外基质合成等作用。作为β-转化生长因子(transforming growth factor-β,TGF-β)的下游反应因子,可与TGF-β共同参与哮喘气道重塑的发生、发展过程。CTGF在哮喘的气道重塑中有着重要的作用,因此针对其治疗即将成为防治哮喘气道重塑的一个新的研究方向。
Connective tissue growth factor (CTGF) is a new growth factor that stimulates fibroblasts to proliferate and secrete collagen. It can promote the proliferation of myofibroblasts, induce cell adhesion, stimulate cell migration and promote extracellular matrix Synthesis and other functions. As a downstream factor of β-transforming growth factor-β (TGF-β), TGF-β can participate in the process of asthma airway remodeling. CTGF plays an important role in the airway remodeling of asthma. Therefore, its treatment is about to become a new research direction in the prevention and treatment of asthma airway remodeling.