在本周《Nature》的一篇报告中,oldstone及其同事阐述了淋巴细胞脉络丛脑膜炎病毒感染的年轻小鼠导致生长改变和葡糖调节的改变。这些发现中引人注目的是:即使明显检出小鼠生长激素缺乏,移植产生生长激素的细胞可使感染鼠正常发育,并证明病毒在脑垂体内复制,但组织学上未能证明被感染鼠垂体有组织损伤。上述发现表明,在功能极度受损的情况下,常规病理检查可能查不出损伤;由 In a report this week in Nature, Oldstone and colleagues describe that young mice infected with lymphocytic choriomeningitis virus lead to altered growth and altered glucose regulation. What is striking from these findings is that even if the growth hormone deficit in mice is apparently detected, the transplantation of growth hormone-producing cells allows the normal development of infected mice and evidences that the virus replicates in the pituitary gland, but is not histologically proven to be infected Pituitary tissue damage. The above findings show that in the case of extremely impaired function, routine pathological examination may not detect damage; from