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作者观察12只健康狗颅内压(ICP)升高对心肌收缩性的影响.用硬脑膜外套囊法使ICP阶梯升高,分别升至6.7,13.3和20.0kPa.结果ICP升至6.7kPa时,除心率显著减慢外,其它指标无明显改变.ICP升至13.3 kPa时,血压升高,心率减慢,心输出量由1.83 L/min升至2.51L/min,LVSP由15 kPa升至22kPa(P<0.01),+dp/dt_(max)由236 kPa /s升至306kPa/s(P<0.01),-dp/dt_(max)由167 kPa/s升至262kPa/s(P<0.01),t—dp/dt_(max)时间由82.ms缩短至62ms(P<0.01),说明心肌收缩性增强.ICP继续升至20.0kPa时,上述指标均继续增高,作者认为这是机体代偿的结果.
The authors observed 12 healthy dogs intracranial pressure (ICP) on the impact of myocardial contractility with the dural capsule method so that the ICP level rise, respectively, rose to 6.7,13.3 and 20.0kPa Results ICP rose to 6.7kPa , Heart rate decreased from 1.83 L / min to 2.51 L / min and LVSP increased from 15 kPa to 13.3 kPa, except heart rate decreased significantly Dp / dt max increased from 236 kPa / s to 306 kPa / s (P <0.01), and dp / dt max increased from 167 kPa / s to 262 kPa / s (P < 0.01), t-dp / dt max decreased from 82.ms to 62ms (P <0.01), indicating that myocardial contractility increased.ICP continue to rise to 20.0kPa, the above indicators continue to increase, the authors believe that this is the body The result of compensation.