1949年Sezary氏对4例病人经过约十年的详细观察之后,清楚地描述了一种与网状内皮细胞异常增生有关的皮肤网状细胞增多症。这种病的临床表现包括较广泛的红皮病,色素沉着,脱皮,手掌和足底有皮裂,以及与之相关的慢性白血病,称为Sezary综合征。Sezary综合征的自然发展史和临床表现与标准的蕈样霉菌病相比较,除了前者有 Sezary’s 1949 detailed examination of four patients after about a decade clearly described a cutaneous reticulocytosis associated with an abnormal proliferation of reticuloendothelial cells. The clinical manifestations of the disease include a wide range of erythroderma, pigmentation, peeling, palmar and plantar skin rupture, and associated chronic leukemia, known as Sezary’s syndrome. The natural history and clinical presentation of Sezary’s syndrome compared with the standard mycosis fungoides, except for the former