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目的：探讨临床护理路径对首发精神分裂症患者服药依从性的影响。方法将80例首发精神分裂症患者随机分为研究组和对照组，每组40例。研究组采用临床护理路径进行护理干预，对照组采用传统整体护理方法进行护理。比较两组患者的服药依从性及复发率。结果干预前两组服药依从性比较差异无显著性（P ＞0．05），干预后两组均较治疗前显著改善（P ＜0．01），研究组显著优于对照组（P＜0．01），出院后研究组复发率显著低于对照组（P＜0．05）。结论实施临床护理路径能有效提高首发精神分裂症患者的服药依从性，降低疾病复发率。“,”Objective To explore the influence of clinical nursing pathway (CNP) on drug compliance of first‐episode schizophrenics .Methods Eighty first‐episode schizophrenics were randomly divided into research and control group of 40 ones each .Research group re‐ceived nursing intervention according to CAP and control according to traditional holistic nursing .Group drug compliance and relapse rate were compared .Results There was no significant group difference in drug compliance before intervention (P > 0 .05) ,drug compliance improved more notably in both groups after intervention compared with pre‐intervention (P< 0 .01) ,so did that in research than in control group (P< 0 .01) ,and relapse rate was significantly lower in research than in control group after discharge (P<0 .05) .Conclusion CNP could effectively boost the drug compliance of first‐episode schizophrenic and re‐duce relapse rate .