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目的组装癌症治疗药物五氟尿嘧啶,构成功能性磁性壳聚糖纳米粒子药物载体。方法用化学共沉淀法制备了Fe3O4纳米颗粒,经优化胶体化学反应技术采用壳聚糖改性。经激光粒度仪、透射电子显微镜,红外光谱以及紫外-可见光谱进行形貌与粒度研究分析。结果其中磁性Fe3O4颗粒,壳聚糖改性磁性Fe3O4,以及载药(五氟尿嘧啶,5-Fu)壳聚糖改性磁性Fe3O4纳米颗粒的粒径分别为8￣12nm,12￣15nm和20￣30nm,颗粒形状呈规则球型;壳聚糖改性作用和改性后纳米磁性Fe3O4载药效果明显。壳聚糖-五氟尿嘧啶(5-Fu)和壳聚糖改性磁性Fe3O4纳米颗粒载药量分别达到15.8%和9.3%。结论上述纳米药物载体在磷酸盐缓冲液中均表现出明显的缓释特性。
Objective To assemble cancer therapeutic drug pentafluorouracil to form a functional magnetic chitosan nanoparticle drug carrier. Methods Fe3O4 nanoparticles were prepared by chemical coprecipitation method and modified by chitosan by the optimized colloidal chemical reaction technique. The morphology and particle size were analyzed by laser particle size analyzer, transmission electron microscopy, infrared spectroscopy and UV-Vis spectroscopy. Results The magnetic Fe3O4 particles, chitosan-modified magnetic Fe3O4 and drug-loaded (pentafluorouracil, 5-Fu) chitosan-modified magnetic Fe3O4 nanoparticles were 8 ~ 12nm, 12 ~ 15nm and 20 ~ 30nm , The shape of the particles is a regular ball; chitosan modification and modified nano-magnetic Fe3O4 drug effect is obvious. Chitosan-fluorouracil (5-Fu) and chitosan-modified magnetic Fe3O4 nanoparticles were 15.8% and 9.3%, respectively. Conclusion The above nano-drug carrier showed obvious sustained release characteristics in phosphate buffer.