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目的 观察猴免疫缺陷病毒 (simian imm unodeficiency virus,SIV ) SIVmac和 SIVmac2 5 1毒株感染猕猴快速进展型死亡的感染特征。方法 用 SIVm ac和 SIVmac2 5 1静脉接种 ,实验性感染 80只恒河猴和 4只食蟹猴 ,定期采集静脉血浆进行病毒分离测定血浆病毒水平 ,间接免疫荧光法测定血浆病毒抗体水平 ,并取淋巴组织进行常规病理组织学检查。结果 84只猕猴感染 SIVmac和 SIVmac2 5 13～ 4个月 ,快速进展型死亡 12只 ,占14.2 %。快速进展型猕猴有高而持续的病毒血症 ,约半数有低抗体水平的特征。 10只快速进展型猕猴的病理组织学检查结果显示 ,淋巴结和脾脏呈现淋巴组织耗竭者占 80 %～ 90 % ,表明快速进展型死亡猴免疫功能已极度低下 ,80 %有合并症发生 ,其中以肠炎为主 ,主要死因为严重免疫衰竭或机会性感染。结论 SIV实验感染猕猴快速进展型死亡猴的特征为高而持续的病毒血症、约半数有低病毒抗体水平和严重的免疫功能受损。
Objective To observe the infection characteristics of simian imm unodeficiency virus (SIV) SIVmac and SIVmac2 51 strains infected with fast-moving death in macaques. Methods Eighty Rhesus macaques and four cynomolgus monkeys were inoculated intravenously with SIVm ac and SIVmac2 5 1. Plasma was collected by venous plasma and virus antibody levels were measured by indirect immunofluorescence. Lymphoid tissue for routine histopathology. Results 84 macaques were infected with SIVmac and SIVmac2 for 13 to 4 months and 12 were rapidly progressive type, accounting for 14.2%. Fast-moving monkeys have high and persistent viremia, with about half of them having low antibody levels. Pathological examination of 10 fast-moving monkeys showed that lymph nodes and spleens showed lymphoid tissue depletion accounting for 80% -90%, indicating that immune function of rapidly evolving dead monkeys has been extremely low and that 80% of them have complications Enteritis, the main cause of death is severe immune failure or opportunistic infections. Conclusion SIV experimentally infected rhesus monkeys with fast-moving death monkeys are characterized by high and persistent viremia, with about half of them having low virus antibody levels and severe impaired immune function.