【摘 要】
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To investigate the role of transforming growth factor-β1 (TGF-β1) in mice with hepatic fibrosis caused by Schistosomiasis Japonica, ELISA ,VG staining and mul
【机 构】
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Department of Infectious Disease, Xiehe Hospital, Tongji Medical University,Wuhan 430022“,”Departmen
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To investigate the role of transforming growth factor-β1 (TGF-β1) in mice with hepatic fibrosis caused by Schistosomiasis Japonica, ELISA ,VG staining and multimedia color hieroglyph quantitative analysis were used to study the change of the serum TGF-β1, liver collagen fiber and reticular fiber in mice. The level of serum TGF-β1 in experimental group was significantly higher than that in control group (P＜0.01 orP＜0.05) 8, 10, 12 weeks after infected by schistosomiasis. After infection, the level of liver collagen fiber and reticular fiber, and that of TGF -β1 increased over time (P＜ 0.01 or P＜0. 05). In mice infected by Schistosomiasis Japonica, the level of TGF-β1 increased with prolongation of infection time, and with the increase of liver collagen fiber and reticular fiber. TGFβ1 plays an important role of immunomodulation in hepatic fibrosis formation caused by Schistosomiasis Japonica.
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