左室扩大是AMI后成活率的重要决定因素。AMI后早期心梗节段伸长和变薄(梗塞区空壁膨展)及非梗塞节段肥厚引起左室扩大。而左室扩大又影响了心功能,导致心力衰竭和死亡。动物实验和人体预初试验表明早期应用血管紧张素转换酶抑制剂卡托普利(开搏通)后,可限制梗塞区室壁膨展和左室慢性进行性扩大。 Left ventricular enlargement is an important determinant of survival after AMI. AMI early myocardial infarction segment elongation and thinning (infarction area wall expansion) and non-infarction segment hypertrophy caused by left ventricular enlargement. The enlarged left ventricle also affects heart function, leading to heart failure and death. Animal experiments and human preliminary tests show that the early application of the angiotensin-converting enzyme inhibitor captopril (Captopril), can limit infarct wall expansion and chronic ventricular enlargement.