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胰腺癌恶性程度高、预后差,目前临床缺乏有效的治疗手段。早期诊断率低、化疗耐药性高和死亡率高是胰腺癌诊治中亟待解决的主要问题。微小RNA是一类长度在19~24 nt的内源性非编码单链小分子RNA,可作为癌基因和抑癌基因在肿瘤的发生、发展、侵袭、转移和耐药等过程中起重要作用,在临床上有望成为诊断、耐药和预后判断的分子标志物。越来越多的研究表明,微小RNA和胰腺癌有着密切的关系,然而其具体机制有待阐明。更加系统深入地研究微小RNA在胰腺癌发生和发展中的变化及其作用,有利于更全面地了解胰腺癌的发病机制。
Pancreatic cancer has a high degree of malignancy and a poor prognosis. Currently, there is a lack of effective clinical treatment. The low rate of early diagnosis, high resistance to chemotherapy and high mortality are the main problems to be solved in the diagnosis and treatment of pancreatic cancer. MicroRNAs are a class of endogenous non-coding single-stranded small RNAs ranging in length from 19 to 24 nt. They can play an important role as oncogenes and tumor suppressor genes in tumorigenesis, development, invasion, metastasis and drug resistance , Which is expected to become a molecular marker for diagnosis, drug resistance and prognosis in clinic. More and more researches have shown that there is a close relationship between microRNA and pancreatic cancer. However, its specific mechanism remains to be elucidated. To study the changes and roles of microRNAs in the occurrence and development of pancreatic cancer more systematically and in-depth is helpful to understand the pathogenesis of pancreatic cancer more fully.