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本文应用体外培养人淋色细胞并进行微核、染色体畸变的检测以及小鼠骨髓微核实验的研究，评价胎盘免疫调节肽（Ｐｌａｃｅｔａｌｉｍｍｕｎｏｒｅｇｕｌａｔｉｎｇｐｏｌｙｐｅｐｔｉｄｅ，ＰＩＰ）遗传毒性和抗突变效应，实验结果表明：胎盘免疫调节肽（００２和００３ｍｌ／ｍｌ）可显著抑制培养人淋巴细胞的自发和γ射线诱发的微核形成以及丝裂霉素Ｃ（ＭＭＣ）诱发的染色体畸变，并能明显抑制环磷酰胺诱发的小鼠骨髓多染性红细胞微核的增加，揭示了胎盘免疫调节肽具有抗突变作用
In this study, we investigated the genotoxicity and anti-mutagenic effect of Placetalimmunoregulatingpolypeptide (PIP) in cultured human lymphocytes in vitro and micronuclei, chromosome aberrations and bone marrow micronucleus test. The results showed that placental immunization Regulated peptides (002 and 003 ml / ml) could significantly inhibit the spontaneous and γ-ray induced micronucleus formation in cultured human lymphocytes and the chromosomal aberrations induced by mitomycin C (MMC), and significantly inhibited the effects of cyclophosphamide Amide-induced increase in mouse bone marrow polychromatic erythrocyte micronuclei revealed that placental immunomodulatory peptides have an anti-mutagenic effect