复旦大学生物医学研究院多名研究人员通过潜心研究,发现人体代谢产物2-羟基戊二酸(2-HG)可诱发神经胶质瘤和白血病,并对其作用机制进行了探索,这一研究成果已于2011年1月18日发表在《癌细胞》杂志(Cancer Cell)上。此前有研究显示,异柠檬酸脱氢酶基因IDH1和IDH2突变频繁发生于神经胶质瘤和白血病中。该突变会促进体内2-HG Researchers at Fudan University’s Institute of Biomedical Research found that 2-hydroxyglutaric acid (2-HG), a human metabolite, can induce gliomas and leukemias through a lot of research, and its mechanism of action was explored The results were published on January 18, 2011 in Cancer Cell. Previous studies have shown that isocitrate dehydrogenase gene IDH1 and IDH2 mutations occur frequently in glioma and leukemia. This mutation promotes 2-HG in vivo