目的　探讨近 5年来粤西北地区上消化道出血 (UGB)的病因及相关因素。方法　将近 5年来2 6 4例上消化道出血住院病人的性别、年龄、发病季节、诱因、出血方式、出血病因进行对比。结果　本地区上消化道出血的首位病因为消化性溃疡 ,其次为急性胃粘膜病变 ,性别、年龄、季节等均为UGB相关因素。结论　上消化道出血病人应建议行内镜检查确诊 ,以指导治疗。如能重视卫生宣教工作 ,可降低UGB发病率。 Objective To investigate the etiology and related factors of upper gastrointestinal bleeding (UGB) in northwest of Guangdong in recent 5 years. Methods The sex, age, season of onset, causes, modes of bleeding and causes of bleeding in 246 inpatients with upper gastrointestinal bleeding in the recent 5 years were compared. Results The first cause of upper gastrointestinal bleeding in this area was peptic ulcer, followed by acute gastric mucosal lesions. The gender, age, and season were all UGB related factors. Conclusion Upper gastrointestinal bleeding patients should be recommended endoscopic diagnosis to guide the treatment. If attention to health education mission, can reduce the incidence of UGB.