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恶性肿瘤的侵袭转移能力是肿瘤治疗的一大难点。近些年来,小分子RNA(miRNA)的出现为研究肿瘤的发生及侵袭转移机制提供了新的思路和途径,微小RNA(miRNA)是一类内源性、保守、稳定的非编码短单链RNA,在转录后水平调节靶基因表达。miRNA在机体发育,细胞增殖、凋亡及肿瘤发生发展等生理和病理过程中发挥重要作用。miR-10b作为微小RNA家族中的一员,在肝癌、乳腺癌、胰腺癌、胶质瘤、垂体瘤、急性髓性白血病等肿瘤组织中都有异常表达,并且与肿瘤的侵袭性和远处转移有密切关系。
The invasion and metastasis of malignant tumor is a major difficulty in cancer treatment. In recent years, the emergence of small RNAs (miRNAs) has provided new ideas and approaches for the study of tumorigenesis and invasion and metastasis mechanisms. MicroRNAs (miRNAs) are a class of endogenous, conserved and stable non-coding short single-stranded RNA regulates target gene expression at post-transcriptional level. MiRNA plays an important role in the physiological and pathological processes such as body development, cell proliferation, apoptosis and tumorigenesis. As a member of the microRNA family, miR-10b is abnormally expressed in tumor tissues such as liver cancer, breast cancer, pancreatic cancer, glioma, pituitary tumor and acute myeloid leukemia, and is associated with tumor aggressiveness and distantness Transfer is closely related.