The coordinated development of human settlement environment and economy is of vital significance to urban sustainable development and urban ecosystem health. Urban human settlement and economic systems exist in urban ecosystems, which are a structural complexity. Therefore the research is being challenged by some uncertain factors between human settlements and economic systems. However most of the researches were focused on its determinate objective aspects and qualitative analyses while less concern on the quantitative evaluation of coordinated development of urban human settlement environment and economy, especially little on its uncertain aspect. At present, the urgent task is to study the coordinated development of urban settlement environment and economy in terms of the effect of uncertainty. This study analyzed the uncertain characteristics, which would be confronted at different stages, such as confirming the index categories, their bound values, and their construction rate, etc. According to the actual urban conditions, many construction principles based on uncertainties are put forward and an indicating system for human settlement and economic evaluation is established. Moreover, the application of fuzzy mathematics presents a new method and a calculation model for the comprehensive assessment of the coordinated development of urban human settlement environment and economy. The application of the method and model in Changsha city of China showed that the assessment results can reflect not only the overall coordination degree of the city, but also the mode of interactive mechanism between urban economic system and human settlement environment. The coordinated development of human settlement environment and economy is of vital significance to urban sustainable development and urban ecosystem health. Urban human settlement and economic systems exist in urban ecosystems, which are a structural complexity. Therefore the research is being challenged by some uncertain factors between Yet most of the researches were focused on its determinate objective aspects and qualitative analyzes while less concern on the quantitative evaluation of coordinated development of urban human settlement environment and economy, especially little on its unstable aspect. At present, the urgent task is to study the coordinated development of urban settlement environment and economy in terms of the effect of uncertainty. which will be confronted at different stages, such as confirming the index categories, their bound values, and their construction rate, etc . According to the actual urban conditions, many construction principles based on uncertainties are put forward and an indicating system for human settlement and economic evaluation is established. Moreover, the application of fuzzy mathematics presents a new method and a calculation model for the comprehensive assessment of the coordinated development of urban human settlement environment and economy. The application of the method and model in Changsha city of China showed that the assessment results can reflect not only the overall coordination degree of the city, but also the mode of interactive mechanism between urban economic system and human settlement environment.