八十年代以来,转移的研究已成为国际上比较关注的课题。而肿瘤转移过程和机制的研究,肿瘤转移的预防、控制和实验治疗的研究,无论在细胞还是分子水平,最终都要依靠适宜的动物模型来进行。因此肿瘤转移动物模型在转移的研究中占有极其重要的地位。近年来,建立人肿瘤裸鼠转移模型已引起学者们广泛的兴趣。从七十年代中期,人们就开始了积极的探索,并获得了长足的进展,现将有关研究成果及头颈肿瘤裸鼠移植模型的研究现状综述如下。 一、转移模型的建立 Since the 1980s, the research on transfer has become a topic of international concern. However, studies on the process and mechanism of tumor metastasis, prevention, control and experimental treatment of tumor metastasis will ultimately depend on appropriate animal models, both at the cell and the molecular level. Therefore, tumor metastasis animal model plays an extremely important role in the study of metastasis. In recent years, the establishment of human tumor metastasis model of nude mice has aroused widespread interest scholars. From the mid-seventies, people began to actively explore and made considerable progress, now the research results and research status of head and neck cancer nude mice transplantation model are summarized below. First, the transfer model of the establishment