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高碘是否和低碘一样会导致脑发育障碍，特别是母体高碘是否会对子代造成脑发育和智力损害，是一项具有重要医学和遗传学意义而尚未进行深入研究的问题。用高碘水喂小鼠复制出高碘甲状腺肿动物模型，对高碘甲状腺肿母鼠生下的１、７、１４、２１和３０日龄仔鼠的脑重量、脑蛋白质和核酸含量进行了测定，并对３０日龄仔鼠的脑形态变化和学习、记忆能力进行了观察。结果表明，与适碘组相比，高碘组小鼠脑重量、蛋白质含量和蛋白质／ＤＮＡ比值、ＲＮＡ含量和ＲＮＡ／ＤＮＡ比值均明显降低，而ＤＮＡ含量升高。３０日龄仔鼠学习、记忆能力下降，并观察到，这些参数的变化多数从７～１４日龄开始。这提示，摄入过量碘同碘缺乏一样，不仅可引起高碘性甲状腺肿，也可对神经系统造成损害，使脑发育落后，脑功能障碍。
Whether high iodine, like low iodine, can lead to brain developmental disorders, especially whether high maternal iodine can cause brain development and intellectual impairment to offspring is an issue that has not been studied in depth with important medical and genetic significance. High iodine water was used to infect mice with high iodine. The animal models of high iodine goiter were reproduced and the brain weights, brain proteins and nucleic acid contents of 1,7,14,21 and 30-day-old offspring born to high iodine thyroiditis mice The changes of brain morphology and learning and memory of 30-day-old pups were observed. The results showed that the brain weight, protein content and protein / DNA ratio, RNA content and RNA / DNA ratio of iodine-treated mice were significantly decreased, while DNA content was increased. 30-day-old offspring learning, decreased memory, and observed that most of these parameters change from 7 to 14 days of age. This suggests that excessive intake of iodine, like iodine deficiency, can cause not only high-iodine goiter but also damage to the nervous system, brain development and brain dysfunction.