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促酰化蛋白是由脂肪细胞分泌的一种生物活性物质 ,是调节脂肪功能与脂肪储备的关键因素之一。促酰化蛋白与其效应细胞表面的特异性受体相互作用 ,在胞内信号转导途径 (包括蛋白激酶C途径 )参与下 ,可调控细胞内甘油三酯合成的关键酶———二酰基甘油转酰酶的活性 ,并影响激素敏感性脂肪酶活性 ,从而促进细胞内甘油三酯的合成 ,并调控脂肪细胞的分化及成脂作用。同时 ,影响糖代谢 ,调节胰岛素的敏感性。促酰化蛋白代谢途径功能失调 ,将引起一系列脂质代谢紊乱 ,并认为与肥胖症、糖尿病和心血管疾病密切相关。
Acrytacin is a biologically active substance secreted by fat cells and is one of the key factors that regulate fat function and fat reserves. Acrytacin interacts with specific receptors on its effector cell surface. With the involvement of intracellular signal transduction pathways (including protein kinase C pathway), acylglycerols, which are key enzymes in the regulation of intracellular triglyceride synthesis, Transacylase activity, and affect the hormone-sensitive lipase activity, thereby promoting intracellular triglyceride synthesis, and regulation of adipocyte differentiation and adipogenic effect. At the same time, affect glucose metabolism, regulate the sensitivity of insulin. Dysregulation of the acylated metabolic pathway leads to a series of lipid metabolism disorders and is believed to be closely linked to obesity, diabetes and cardiovascular disease.