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1985～1986年美国菌痢病原体的监测中,约4％宋氏志贺氏菌对 TMP-SMZ 耐药。1987年7月初,在北卡罗莱纳州举行“多彩之家”年会的参加者中,发生了一次多种耐药的宋氏志贺氏菌病暴发。以后,在其他州发生过4次这种宋氏志贺氏菌病病例的集聚,引起有关方面的警惕。对年会参加者调查的初步结果表明,270名应答者中,157名(58％)有过急性腹泻,与起初估计12000名参加者中≥50％发生急性胃肠炎相符。病原菌为对氨苄青霉素、四环素和 TMP-SMZ 耐药的宋氏志贺氏菌,来自26个(?)的75名参加者,和他们的14名接触
About 4% of S. Shigella was resistant to TMP-SMZ in the surveillance of the U.S. dysentery pathogens from 1985 to 1986. In July 1987, a multi-drug resistant outbreak of Shigella spp. Occurred among participants of the annual Colorful House in North Carolina. Since then, there have been four such cases of Shigella spp. Clustering in other states, arousing vigilance on the parties concerned. Initial results of the annual meeting participants survey revealed that 157 (58%) of 270 respondents had had an acute diarrhea consistent with> 50% of acute gastroenteritis in an initial estimate of 12,000 participants. Pathogenic bacteria were Shigella sonnei resistant to ampicillin, tetracycline and TMP-SMZ, 75 participants from 26 (?), And 14 of their contacts