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目的:研究癫痫“从肝论治”、“从痰论治”的复方柴胡疏肝汤及定痫丸对戊四氮(PTZ)慢性点燃大鼠痫性发作的影响。方法:建立大鼠PTZ慢性点燃的癫痫模型,选取完全点燃大鼠随机分为4组,即生理盐水组(A组)、丙戊酸钠组(B组)、定痫丸组(C组)、柴胡疏肝汤组(D组),连续灌胃给药28天,于给药第7、14、21及28天观察大鼠阵发性痉挛发作潜伏期、痫性发作级别以及强直性惊厥发生率。结果:C组与D组在各用药时间点均能不同程度延长PTZ慢性点燃大鼠的阵发性痉挛发作潜伏期,与A组相比有显著性差异(P>0.05或P>0.01),与B组作用相当(P>0.05),而C组与D组无显著性差异(P>0.05)。结论:癫痫“从肝论治”的复方柴胡疏肝汤、“从痰论治”的复方定痫丸均能明显抑制PTZ致痫大鼠的痫性发作,有明显的抗癫痫作用,但两复方在时效关系中可能存在差异。
Objective: To study the effects of Fufang Chaihu Shugan Decoction and Dingxian Wan on the epileptic seizures in rats with pentylenetetrazole (PTZ) chronic ignition induced by epilepsy. Methods: A rat model of epilepsy induced by chronic ignition of PTZ was established. The rats were randomly divided into 4 groups: normal saline (group A), sodium valproate (group B), Dingxiewan (group C) , Chaihu Shugan decoction group (group D), continuous intragastric administration for 28 days, on the 7th, 14th, 21st and 28th day after administration, the latency of onset of paroxysmal spasm, level of seizure and tonic seizure Occurrence rate. Results: The latent period of paroxysmal spasm in PTZ chronic ignition rats was prolonged at different time points in groups C and D, which was significantly different from that in group A (P> 0.05 or P> 0.01) The effect of group B was similar (P> 0.05), but there was no significant difference between group C and group D (P> 0.05). Conclusion: epilepsy “from the liver on” the compound Chaihu Shugan Tang, “from the phlegm theory,” the decoction of epididymal PANT can significantly inhibit PTZ epileptic seizures in rats with significant anti- Epilepsy, but the two prescriptions may be different in the aging relationship.