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目的 采用图论分析方法探讨早期阶段双相障碍Ⅰ型躁狂患者脑功能网络小世界属性的特点及其与临床资料的关系.方法 对符合美国精神障碍诊断统计手册第4版(DSM-Ⅳ)诊断标准的双相Ⅰ型躁狂发作且病程小于2年的患者22例及性别、年龄与患者匹配的正常健康对照22例进行静息态磁共振扫描,以贝克-拉范森躁狂评定量表(BRMS)评估患者临床症状,在Matlab平台上应用SPM及DPARSF软件提取AAL90个脑区的时间序列,采用Gretna工具包建立功能连接矩阵并计算网络参数,采用双样本t检验比较两组差异.结果 与正常对照组相比,双相Ⅰ型躁狂组在较宽稀疏度范围内(稀疏度为13％,16％～31％)特征路径长度显著大于对照组(P＜0.05),全局效率在稀疏度为18％时显著低于对照组(P＜0.05);稀疏度阈值为18％时,双相Ⅰ型躁狂组BRMS量表分与特征路径长度成正相关(r=0.426,P=0.048)、与全局效率成负相关.结论 患者脑功能网络呈现网络效率下降、特征路径减小等整体性改变,反映了皮质和皮质下连接的异常.特征路径长度及全局效率可能作为病情客观诊断的神经影像标记.“,”Objective To explore the small world characters of patients in the early stage of bipolar disorder by using graph theory.Methods Resting-state fMRI data were collected from 22 patients who met with DSMⅣ diagnostic criteria for current manic episode and with duration less than 2 years,and 22 age-and gendermatched healthy control subject.Time series of AAL 90 regions were extracted for each subject and correlation matrices were analyzed.Results Compared with health controls,bipolar disorder patients showed significantly decreased global efficiency in sparsity threshold of 18％ and longer characterized path length in sparsity threshold of 13％,16％-31％ (P＜0.05).BRMS score was positively correlated with characterized path length (r=0.426,P=0.048) and negatively correlated with global efficiency (r=-0.426,P=0.048)in sparsity threshold of 18％ in bipolar manic patients.Conclusion The alteration of global efficiency and characterized path length reflected abnomality of connection between cortical and sub-cortical regions.Characterized path length could be a possible neuroimaging marker of bipolar-I mania.