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二磷酸果糖(FDP)的国际命名是1,6-二磷酸果糖(fructose-1,6-diphosphate),供药用的为其钠盐,它能调节葡萄糖代谢中多种酶系的活性,为一种能恢复,改善细胞代谢的药物,可增加能量利用,加速组织修复,以恢复正常功能。外源性 FDP 不能透过细胞膜,主要作用方式可能是与细胞膜相互作用,激活磷酸果糖激酶(PFK),增加细胞内高能磷酸键和细胞内 ATP 浓度,在细胞表面由相互作用所激发的原发变化,可能使 K~+内流增加,从而提高细胞内的极化。FDP 的应用机理是,当局部及全身缺血缺氧时,无氧糖酵解在磷酸果糖激酶(PFK)步骤即被酸中毒阻断,补充外源性 FDP 作为高能磷酸基质,可
The international designation for fructose diphosphate (FDP) is fructose-1,6-diphosphate, a pharmaceutically acceptable salt thereof, which modulates the activity of various enzymes in glucose metabolism as A kind of medicine that can restore and improve cell metabolism can increase energy utilization and accelerate tissue repair to restore normal function. Exogenous FDP can not penetrate the cell membrane, the main mode of action may be the interaction with the cell membrane, activate phosphofructokinase (PFK), increase intracellular high-energy phosphate bond and intracellular ATP concentration, the primary cell surface stimulated by the interaction of the primary Changes may increase K ~ + influx, thereby increasing intracellular polarization. The mechanism of application of FDP is that, when local and systemic ischemia and hypoxia, anaerobic glycolysis is blocked by acidosis during the step of phosphofructokinase (PFK) and supplemented with exogenous FDP as a high-energy phosphate matrix