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目的 研究肝细胞癌 (hepatocellularcarcinoma ,HCC)经导管动脉化疗栓塞 (transcatheterarterialchemoembolization ,TACE)后残癌组织微血管密度 (microvesseldensity ,MVD)、微血管直径的情况及其意义。方法 经病理证实的HCC 63例 ,包括单纯手术切除42例 (对照组 ) ,TACE术后行Ⅱ期手术切除 2 1例 (TACE组 ) ,TACE组患者手术前接受 1～ 2次不等的TACE术治疗 ,均按统一规范标准给予化疗药物灌注 +栓塞治疗。对手术切除标本进行免疫组化染色 ,其中TACE组取病灶边缘残存肿瘤部分 ,检测肿瘤组织的MVD、微血管直径。结果 对照组MVD值为 5 1.69± 18.17,TACE组MVD值为 5 8.5 7± 15 .75 ,二者之间比较无显著性差异 (t=1.48,P >0 .0 5 ) ;对照组微血管直径为 ( 17.62± 10 .5 4) μm ,TACE组微血管直径为 ( 15 .79± 7.65 ) μm ,二者之间比较无显著性差异 (t =0 .71,P >0 .0 5 )。结论 TACE术很难彻底消除肿瘤血供 ,术后残癌组织可通过各种途径重新生成丰富血供
Objective To investigate the significance of microvessel density (MVD) and microvessel diameter of residual cancer tissue after transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). Methods Totally 63 HCC patients were pathologically confirmed, including 42 cases of simple surgical resection (control group), 21 cases of TACE group (TACE group), TACE group received 1 ~ 2 times of TACE before operation Surgery, according to uniform standards for chemotherapy drug infusion + embolization. Surgical resection of specimens for immunohistochemical staining, TACE group lesions taken from the edge of the tumor part of the tumor tissue MVD, microvascular diameter. Results The MVD of the control group was 5 1.69 ± 18.17 and the MVD of the TACE group was 5 8.5 7 ± 15 .75 (t = 1.48, P> 0.05). The microvessel diameter Was (17.62 ± 10. 54) μm, and the diameter of capillaries in TACE group was (15.79 ± 7.65) μm. There was no significant difference between the two groups (t = 0.71, P> 0.05). Conclusion TACE is difficult to completely eliminate the blood supply to the tumor, after which the residual cancer tissue can regenerate a rich blood supply through various ways