论文部分内容阅读
目的 :研究血管内皮生长因子 ( VEGF)和微血管密度 ( MVD)与大肠癌分期以及术后发生肝转移的关系。方法 :检测 1 60例大肠癌标本中 VEGF和 MVD的表达并结合随访结果分析。结果 :VEGF和 MVD与大肠癌的临床分期密切相关 :Dukes C期的 VEGF和 MVD表达高于 B期 ,差异有显著性 ( P<0 .0 1 ) ;术后发生肝转移组 VEGF和 MVD表达高于无转移组 ,差异有显著性 ( P<0 .0 1 )。结论 :检测大肠癌病灶中 MVD和 VEGF的表达能预测患者的临床分期 ,MVD和 VEGF过度表达的患者 ,术后发生肝转移的危险性大
Objective: To investigate the relationship between vascular endothelial growth factor (VEGF) and microvessel density (MVD) and staging of colorectal cancer and postoperative liver metastasis. Methods: The expression of VEGF and MVD in 160 specimens of colorectal cancer was detected and analyzed with follow-up results. Results: The clinical stages of colorectal cancer were closely related to the expression of VEGF and MVD. The expression of VEGF and MVD in Dukes C stage was higher than that in B stage (P <0.01). The expression of VEGF and MVD in postoperative liver metastasis Higher than non-metastasis group, the difference was significant (P <0.01). Conclusion: The detection of MVD and VEGF expression in colorectal cancer lesions can predict the clinical stage of patients, MVD and VEGF over-expression in patients with liver transplantation after the risk of large